Since April, four staff members have died at the Western Cape's largest hospital after contracting Covid-19.
Sister Hendroleen Maartins, who has worked at the hospital for 24 years, said management was not supporting staff.
Nursing unions are working closely with staff, management and the Department of Labour to find a way forward.
The South African Federation of Trade Unions' secretary in the Western Cape, Andre Adams, wants management to put a risk assessment in place for all workers.
The unions have asked management to supply workers with PPE as well as creating risk-assessment and social-distancing protocols in the hospital.