Dr. Anthony Fauci and other national health leaders have said that African Americans need to take the COVID-19 vaccine to protect their health. What Fauci and others have not stated is that if African Americans don’t take the vaccine, the nation as whole will never get to herd immunity. The concept of herd immunity, also referred to as community immunity, is fairly simple. When a significant proportion of the population, or the herd, becomes immune from the virus, the entire population will have some acceptable degree of protection. Immunity can occur through natural immunity from personal infection and recovery, or through vaccination. Once a population reaches herd immunity, the likelihood of person-to-person spread becomes very low.The big lie is one of omission. Yes, it is true that African Americans will benefit from the COVID vaccine, but the full truth is that the country needs African Americans and other population subgroups with lower reported COVID-19 vaccine acceptability rates to take the vaccine. Without increased vaccine acceptability, we stand little to no chance of communitywide protection. I am an epidemiologist and health equity scholar who has been conducting research in the African American community for 20 years. Much of my work focuses on strategies to increase community engagement in research. I see a significant opportunity to improve COVID vaccine acceptance in the African American community. Doing the coronavirus mathAbout 70% of people in the U.S. need to take the vaccine for the population to reach herd immunity. Whites make up about 60% of the U.S. population. So, if every white person got the vaccine, the U.S. would still fall short of herd immunity. A recent study suggested that 68% of white people would be willing to get the COVID-19 vaccine. If these estimates hold up, that would get us to 42%. African Americans make up more than 13% of the American population. But if up to 60% of African Americans refuse to take the vaccine, as a recent study suggests, it will be difficult to reach that 70% threshold likely needed to reach herd immunity. Latinos make up just over 18% percent of the population. A study suggests that 32% percent of Latinos could reject a COVID vaccine. Add the 40% to 50% rejection rates among other population subgroups and herd immunity becomes mathematically impossible. Further exacerbating the problem is that mass vaccination alone won’t achieve herd immunity, as the effect of COVID vaccines on preventing virus transmission remains unclear. Ongoing preventive measures will likely still be needed to stop community spread. As the resistance to facts and science continues to grow, the need for credible information dissemination and trust-building related to vaccines becomes more important.My research offers some possible explanations for lower vaccination rates among Blacks. Historical wrongs, like the Tuskegee Syphilis Experiments, which ended in 1972, have played a major role in contributing to Black mistrust of the health care system. In another case, the “immortal”