The nasty accident occurred at Kinoni Trading Centre at around 1pm when a speeding Toyota Premio in which the deceased were tarvelling rammed into a trailer.
Police identified the driver of the car as Yasin Sseyonjo, a resident of Mateete Trading Centre in Sembabule District.
Eyewitnesses said the driver of the car lost control of the vehicle ramming into a trailer that was traveling to Kampala from Mbarara.
The Southern Regional Police Spokesperson, Mr Muhammad Nsubuga blamed the accident on reckless driving by the saloon car driver.
"By the time of the accident, the ill-fated saloon car had six occupants which is against the current guidelines on fighting Covid -19 which recommend only three," he said.