"What we are seeing today is different from March and April. It is extraordinarily widespread. It's into the rural as equal urban areas," Birx, the White House coronavirus task force coordinator, told CNN's Dana Bash on "State of the Union."

Birx stressed that Americans need to follow health recommendations, including wearing a mask and practicing social distancing.

"To everybody who lives in a rural area, you are not immune or protected from this virus," Birx said. "If you're in multi-generational households, and there's an outbreak in your rural area or in your city, you need to really consider wearing a mask at home, assuming that you're positive, if you have individuals in your households with comorbidities."

"This epidemic right now is different and it's more widespread and it's both rural and urban," she added.

A new ensemble forecast, published by the US Centers for Disease Control and Prevention, projects more than 173,000 American deaths by August 22, and former US Food and Drug Administrator Dr. Scott Gottlieb warned on CNBC last month that the coronavirus death toll could double to 300,000 deaths by the end of the year, if the country doesn't change its trajectory.

On Sunday, Birx would not give a projection of how many deaths the US would see by the end of year, but she said a death toll largely depends on southern and western states to maintain and accelerate their mitigation efforts. Those states have become hot spots for the virus.

"It's not super spreading individuals, it's super spreading events and we need to stop those. We definitely need to take more precautions," Birx told Bash.

Birx's comments come as the US has reported more coronavirus cases and deaths than any other country.

As of Sunday, the US had reported more than 4.6 million cases of Covid-19 and at least 154,449 Americans have died, according to data from the Johns Hopkins University.

This is a breaking news story and will be updated.