It’s important to understand the two sub-types of ATTR-CM, wild-type and hereditary. Wild-type ATTR-CM, the most common form, is usually associated with men over the age of 60 and is not caused by a genetic mutation. Most wild-type patients are White. The second type, hereditary ATTR-CM, is inherited from a relative and is due to genetics.[1],[1],[1], Hereditary ATTR-CM disproportionately affects the African American community because the most common mutation associated with hereditary ATTR-CM in the U.S. is V122I and is found almost exclusively in African Americans.ii,[1],[1] This series will take a closer look at the signs and symptoms of hereditary ATTR-CM, while exploring the often-complicated journey to diagnosis for patients living with this condition.